Two Sample Logo: a graphical representation of the differences between two sets of sequence alignments
نویسندگان
چکیده
SUMMARY Two Sample Logo is a web-based tool that detects and displays statistically significant differences in position-specific symbol compositions between two sets of multiple sequence alignments. In a typical scenario, two groups of aligned sequences will share a common motif but will differ in their functional annotation. The inclusion of the background alignment provides an appropriate underlying amino acid or nucleotide distribution and addresses intersite symbol correlations. In addition, the difference detection process is sensitive to the sizes of the aligned groups. Two Sample Logo extends WebLogo, a widely-used sequence logo generator. The source code is distributed under the MIT Open Source license agreement and is available for download free of charge.
منابع مشابه
Two Sample Logo User Manual
Two Sample Logo is a procedure for discovery of statistically significant position-specific differences in residue compositions between two multiple sequence alignments, as well as for graphical representation of those differences. It was proposed by Vacic, Iakoucheva and Radivojac [11], and implemented as a web application (available at http://www.twosamplelogo.org) and as a command line progr...
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عنوان ژورنال:
- Bioinformatics
دوره 22 12 شماره
صفحات -
تاریخ انتشار 2006